Posting for Mark Perloe, MD, moderator for the AnCan virtual support for low- to intermediate-risk PCa on polygenic risk scores (PRS).:
Mark Perloe
Fri, Apr 11, 10:02 AM (3 days ago)
to me
While the salivary PRS could be a major improvement over PSA in predicting prostate cancer risk I believe that it should be seen as a screening tool. I believe calling it diagnostic is a bit misleading.
Based on your BARCODE1 polygenic risk score, your estimated lifetime absolute risk of developing prostate cancer is approximately 99.96%.
This figure reflects the log-additive nature of risk in polygenic models and assumes no other modifying factors like protective environmental influences, lifestyle, or screening interventions. While this does not guarantee diagnosis, it places you in the highest possible genetic risk tier.
Now when it comes to AIs, we must proceed cautiously. What this could be is akin to "Every man will die with PCa, some will die from it." Then there is the fact that I have been diagnosed at T1c. <sigh> More time added to my AS sentence 😉.
Interesting. Years ago, I was one of the first customers at 23&me. Among other things, back then, it said I was low-risk for prostate cancer. ALso, low-risk for MI.
I ended up with both,
AS sentence? It would be better to avoid it if we could. It's not the "free ride" some might tink with biopsies, MRIs, etc. But would it better to get radiation or surgery from the get-go?
Posting for Mark Perloe, MD, moderator for the AnCan virtual support for low- to intermediate-risk PCa on polygenic risk scores (PRS).:
Mark Perloe
Fri, Apr 11, 10:02 AM (3 days ago)
to me
While the salivary PRS could be a major improvement over PSA in predicting prostate cancer risk I believe that it should be seen as a screening tool. I believe calling it diagnostic is a bit misleading.
Mark Perloe
Sherman Oaks, CA
Quite interesting. I went and got the SNPs list from the BARCODE1 study and asked my grad student (ChatGPT) to cross reference it to my 23&Me data.
Here's the bad news:
====================================================
Based on your BARCODE1 polygenic risk score, your estimated lifetime absolute risk of developing prostate cancer is approximately 99.96%.
This figure reflects the log-additive nature of risk in polygenic models and assumes no other modifying factors like protective environmental influences, lifestyle, or screening interventions. While this does not guarantee diagnosis, it places you in the highest possible genetic risk tier.
====================================================
Now when it comes to AIs, we must proceed cautiously. What this could be is akin to "Every man will die with PCa, some will die from it." Then there is the fact that I have been diagnosed at T1c. <sigh> More time added to my AS sentence 😉.
Interesting. Years ago, I was one of the first customers at 23&me. Among other things, back then, it said I was low-risk for prostate cancer. ALso, low-risk for MI.
I ended up with both,
AS sentence? It would be better to avoid it if we could. It's not the "free ride" some might tink with biopsies, MRIs, etc. But would it better to get radiation or surgery from the get-go?
Incapable of humor, no? Especially when it comes to AS.
I find the whole experience funny. I have written about PSA prison and more.
Sorry I sounded so serious.
You missed the "Putting the Glee Back in Gleason" contestt, which was all about prostate.
https://howardwolinsky.substack.com/p/yes-you-can-laugh-at-prostate-cancer?utm_source=publication-search
Then you are really going to love my opus and it's almost finished.
Title:
I get to keep my balls!
…at least for another six months.
Well, not to be too literal, I think your balls are safe.
Looking forward to it.